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Baker Mayfield threw for 328 yards and four touchdowns and 12th-ranked Oklahoma held off Iowa State 34-24 on Thursday night for its sixth straight victory.
Playing in their first Thursday night game since 2013, the Oklahoma Sooners (6-2, 5-0) will travel to Ames to take on Iowa State (1-7, 0-5) at 6:30 p.m.
Oklahoma State enters the meat of its conference schedule when Iowa State comes to Stillwater.
The Preseason All-Big 12 team was announced Wednesday morning and it features nine Sooners and three Cowboys.